Key result
L-Fabp knockout mice fed a Western diet were protected against obesity and hepatic steatosis compared to controls, supported by an approximately threefold increase in serum lactate.
Population
Liver fatty acid-binding protein knockout (L-Fabp-/-) mice and C57BL/6J controls
Comparison
High-fat Western diet vs C57BL/6J controls fed the same high-fat Western…
Design
Preclinical
Follow-up
up to 18 weeks
Authors
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L-Fabp inhibition merits exploration in diet-induced steatosis; leaves open translation to human NAFLD therapy.
L-Fabp knockout protects mice against Western diet-induced obesity and hepatic steatosis by shifting energy substrate use from fat to carbohydrate.
Newberry et al. (2006) studied Western diet-induced obesity and hepatic steatosis. L-Fabp knockout vs. C57BL/6J controls was evaluated on Obesity and hepatic triglyceride accumulation. L-Fabp knockout mice fed a Western diet were protected against obesity and hepatic steatosis compared to controls, supported by an approximately threefold increase in serum lactate.
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