Key result
A carbohydrate-rich meal induced a 2.2-fold increase in adipose tissue lipoprotein lipase activity in lean subjects without increasing immunoreactive mass or mRNA levels, indicating posttranslational activation.
Why the study?
Does a carbohydrate-rich meal alter lipoprotein lipase activity, immunoreactive mass, and mRNA levels in the adipose tissue of lean and obese subjects?
Population
21 human subjects (15 obese, 6 lean)
Comparison
Carbohydrate-rich meal vs Before meal and lean vs. obese comparison
Design
Other
Follow-up
4 hours
Authors
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Posttranslational LPL activation after carbohydrate meals needs confirmation in obese subjects; leaves open effects on clinical lipid management.
Observational (n=21)
No
Does a carbohydrate-rich meal alter lipoprotein lipase activity, immunoreactive mass, and mRNA levels in the adipose tissue of lean and obese subjects?
Effect estimate: 2.2-fold increase
p-value: p=<0.05
The increase in adipose tissue LPL activity in response to feeding in lean subjects occurs through posttranslational activation rather than increased protein or mRNA synthesis.
Ong et al. (1989) conducted an observational in Obesity (n=21). High-carbohydrate test meal vs. Fasting state was evaluated on Total adipose tissue lipoprotein lipase (LPL) activity in response to meal in lean subjects (2.2-fold increase, p=<0.05). A carbohydrate-rich meal induced a 2.2-fold increase in adipose tissue lipoprotein lipase activity in lean subjects without increasing immunoreactive mass or mRNA levels, indicating posttranslational activation.
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