What question did this study set out to answer?

To examine whether circulating cytokines, IGF-I, and APOE genotype associate with the presence and severity of delirium in acutely ill older medical inpatients.

October 13, 2008Age and Ageing

Cytokines and IGF-I in delirious and non-delirious acutely ill older medical inpatients

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Authors

DADimitrios AdamisUniversity College Dublin MLMichael P. LunnUCL Biomedical Research Centre FMFinbarr C. MartinKing's College London

Discussion

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Implication

Prospective longitudinal study observes that lower IGF-I and IL-1RA associate with delirium in older inpatients, suggesting a neuroprotective deficiency in acute cognitive decline.

Key Points

To examine whether circulating cytokines, IGF-I, and APOE genotype associate with the presence and severity of delirium in acutely ill older medical inpatients.
Prospective longitudinal study of 67 acutely ill medical inpatients aged 70 years and older assessed every 3–4 days across up to 4 visits (205 total observations).
Delirium presence and severity were evaluated using CAM, DRS, and MMSE, while illness severity was scored using APACHE II.
Blood assays quantified IL-1alpha, IL-1beta, IL-1RA, IL-6, TNF-alpha, IFN-gamma, LIF, IGF-I, and APOE genotype, analyzed via mixed-effects models and generalized estimating equations.
Significantly lower circulating levels of neuroprotective markers IGF-I and IL-1RA associate with the presence of delirium (P < 0.05).
Higher delirium severity on the DRS scale is significantly associated with lower IGF-I and elevated IFN-gamma levels (P < 0.05).
Other pro-inflammatory cytokines, overall illness severity, and the APOE epsilon 4 allele show no significant association with delirium occurrence or severity.

Cite This Study

Adamis et al. (2008) studied this question.

synapsesocial.com/papers/6a0de9af88250cfcc2a53bca https://doi.org/10.1093/ageing/afp014

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Implication

Prospective longitudinal study observes that lower IGF-I and IL-1RA associate with delirium in older inpatients, suggesting a neuroprotective deficiency in acute cognitive decline.

Cytokines and IGF-I in delirious and non-delirious acutely ill older medical inpatients

Discussion

Member takes

Implication

Key Points

Cite This Study

Cytokines and IGF-I in delirious and non-delirious acutely ill older medical inpatients

Discussion

Member takes

Implication

Key Points

Cite This Study

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