Key result
Higher inflammatory biomarkers are linked to depressed mood in men with HIV, but not women.
Why the study?
Depressive symptoms are common in people with HIV, and aging individuals experience increasing inflammation, but the impact of chronic inflammation on depressed mood in this population is unclear.
Are higher levels of plasma inflammation biomarkers associated with depressed mood in aging people with HIV?
Observational (n=78)
Yes
Are higher levels of plasma inflammation biomarkers associated with depressed mood in aging people with HIV?
Effect estimate: r = 0.295
p-value: p=0.0083
Elevated plasma inflammation biomarkers (d-dimer, IL-6, CRP) are associated with depressed mood in aging men with HIV, but not in women.
Sex-specific association in men with HIV is hypothesis-generating; leaves open whether targeting inflammation improves mood.
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Ellis et al. (2020) conducted an observational in HIV (n=78). Plasma inflammation biomarkers was evaluated on Depressed mood assessed using the Beck Depression Inventory (BDI)-II (r = 0.295, p=0.0083). Elevated plasma inflammatory biomarkers were significantly associated with depressed mood in men with HIV (r=0.348; 95% CI 0.111-0.547; p=0.0049), but not in women.
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