Key result
Hypercortisolemic depression in postmenopausal women was associated with greater visceral fat depots at L1 compared to normocortisolemic depression (113.0 vs 74.5 cm2; p=0.04).
Why the study?
Is hypercortisolemia in postmenopausal women with major depression associated with increased intra-abdominal fat and insulin resistance?
Population
45 postmenopausal women, including 22 with major depression and 23 age-matched healthy controls
Comparison
Major depression with hypercortisolemia vs Normocortisolemic depressed patients and healthy…
Design
Case-control
Authors
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May link hypercortisolemia to visceral adiposity in postmenopausal depression; hypothesis-generating and should not yet change practice.
Case-Control (n=45)
Is hypercortisolemia in postmenopausal women with major depression associated with increased intra-abdominal fat and insulin resistance?
p-value: p=0.04
Hypercortisolemia in depressed postmenopausal women is associated with increased visceral fat and insulin resistance, potentially explaining the increased cardiovascular risk in major depression.
Weber-Hamann et al. (2002) conducted a case-control in Major depression (n=45). Hypercortisolemic depression vs. Normocortisolemic depression and healthy controls was evaluated on Intra-abdominal fat at L1 and L4 (p=0.04). Hypercortisolemic depression in postmenopausal women was associated with greater visceral fat depots at L1 compared to normocortisolemic depression (113.0 vs 74.5 cm2; p=0.04).