Key result
Vernakalant hydrochloride appears effective in terminating recent-onset atrial fibrillation, but is not efficacious in long-lasting atrial fibrillation and atrial flutter.
Why the study?
Is vernakalant hydrochloride effective and safe for the treatment of atrial fibrillation?
Is vernakalant hydrochloride effective and safe for the treatment of atrial fibrillation?
Vernakalant is a promising atrial-selective antiarrhythmic agent that is effective for the pharmacological termination of recent-onset atrial fibrillation without significant ventricular proarrhythmic toxicity.
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May inform selective use in recent-onset AF; leaves open efficacy in persistent AF/flutter pending RCTs.
Kozłowski et al. (2009) conducted a review in Atrial fibrillation. Vernakalant hydrochloride was evaluated. Vernakalant hydrochloride appears effective in terminating recent-onset atrial fibrillation, but is not efficacious in long-lasting atrial fibrillation and atrial flutter.
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