Risk Factors for Delirium and Cognitive Decline Following Coronary Artery Bypass Grafting Surgery: A Systematic Review and Meta‐Analysis
Key result
Preoperative depression, cognitive impairment, and prior stroke are linked to post-CABG delirium and cognitive decline.
- n=60,479
Why the study?
Delirium and cognitive decline are common complications after CABG, but comprehensive identification of preoperative, intraoperative, and postoperative risk or protective factors across time was needed.
What are the risk factors associated with delirium and cognitive decline in patients undergoing CABG?
Comparison
Risk or protective factors for delirium and cognitive decline vs their absence
Design
Systematic review and random-effects meta-analysis
Authors
Discussion
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Member takes
Implication
May warrant preoperative screening for depression and cognitive impairment before CABG; confirms modifiable targets in large-scale evidence.
Study Design
Type
Meta-Analysis (n=60,479)
Structured PICO
What are the risk factors associated with delirium and cognitive decline in patients undergoing CABG?
P
Population
60,479 patients who underwent coronary artery bypass grafting (CABG) from 97 studies
I
Intervention
Presence of preoperative, intraoperative, and postoperative risk factors
C
Comparator
Absence of risk factors
O
Outcome
Post-CABG delirium or cognitive declinesafety
Identifies key preoperative, intraoperative, and postoperative risk factors for delirium and cognitive decline following CABG, highlighting depression and cognitive impairment as potentially modifiable targets.
Cite This Study
Greaves et al. (2020) conducted a meta-analysis in Post-CABG delirium and cognitive decline (n=60,479). Preoperative, intraoperative, and postoperative risk factors was evaluated on Delirium and cognitive decline. Preoperative depression, cognitive impairment, and stroke history were identified as significant risk factors for delirium and cognitive decline following CABG in a meta-analysis of 60,479 patients.