What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Unmedicated hypertension (n=77). Intervention: Age. Primary outcome: Correlation of 24-hour pulse pressure with age (r=0.68, p=<0.001).

What question did this study set out to answer?

To investigate how age affects pulse pressure and evaluate the physiological contribution of stroke volume versus arterial compliance in untreated hypertensive men with equivalent mean arterial pressure.

October 1, 1999HypertensionOpen Access

Contribution of Stroke Volume to the Change in Pulse Pressure Pattern With Age

Q: What are the key findings of this study?

In unmedicated hypertensive men, age-related changes in stroke volume significantly accounted for changes in pulse pressure before age 50 (r=0.5, P<0.001), but its contribution decreased thereafter.

Q: What question did this study set out to answer?

To investigate how age affects pulse pressure and evaluate the physiological contribution of stroke volume versus arterial compliance in untreated hypertensive men with equivalent mean arterial pressure.

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Key result

In unmedicated hypertensive men, age-related changes in stroke volume significantly accounted for changes in pulse pressure before age 50 (r=0.5, P<0.001), but its contribution decreased thereafter.

Population

77 unmedicated hypertensive men, aged 17 to 76 years, with daytime mean arterial pressure between 95 and 114…

Design

Cross-sectional

Authors

JAJosé AlfieHospital Italiano de Buenos Aires GWGabriel WaismanHospital Italiano de Buenos Aires CGCarlos R. GalarzaHospital Italiano de Buenos Aires

Discussion

Member takes

Implication

May explain early pulse pressure rise in hypertensive men; leaves open later mechanisms and needs prospective validation.

Key Points

To investigate how age affects pulse pressure and evaluate the physiological contribution of stroke volume versus arterial compliance in untreated hypertensive men with equivalent mean arterial pressure.
Evaluated 77 unmedicated men aged 17 to 76 years with daytime mean arterial pressure between 95 and 114 mm Hg.
Measured supine, upright, and 24-hour ambulatory pulse pressure alongside stroke index, stroke volume, and arterial compliance (SV/PP ratio).
Supine, upright, and 24-hour pulse pressure demonstrated curvilinear relationships with age (r=0.55, r=0.56, and r=0.68, respectively; P<0.001), exhibiting a transition point at age 50 years.
In men under 50 years old, 24-hour pulse pressure correlated positively with stroke volume (r=0.5, P<0.001) and negatively with arterial compliance (r=-0.37, P<0.01).
In men aged 50 years and older, 24-hour pulse pressure correlated inversely with arterial compliance (r=-0.5, P<0.01) with no significant contribution from stroke volume.

Study Design

Type

Cross-Sectional (n=77)

Structured PICO

Population

77 unmedicated hypertensive men, aged 17 to 76 years, with daytime mean arterial pressure between 95 and 114 mm Hg.

Outcome

Effect of age on pulse pressure and its underlying mechanisms (stroke volume and arterial compliance)surrogate

Main Result

Effect estimate: r=0.68

p-value: p=<0.001

In unmedicated hypertensive men, the age-related change in stroke volume significantly accounts for changes in pulse pressure during young adulthood, but its contribution decreases after age 50.

Cite This Study

Alfie et al. (1999) conducted a cross-sectional in Unmedicated hypertension (n=77). Age was evaluated on Correlation of 24-hour pulse pressure with age (r=0.68, p=<0.001). In unmedicated hypertensive men, age-related changes in stroke volume significantly accounted for changes in pulse pressure before age 50 (r=0.5, P<0.001), but its contribution decreased thereafter.

synapsesocial.com/papers/6a0dec026e03bc61cb09fc0b https://doi.org/10.1161/01.hyp.34.4.808

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Contribution of Stroke Volume to the Change in Pulse Pressure Pattern With Age

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Contribution of Stroke Volume to the Change in Pulse Pressure Pattern With Age

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Also Consider

Also Consider