Key result
Inclisiran lowers LDL-C by ~57% at 12 months in patients with CAD.
Why the study?
Clinical trial results show inclisiran lowers LDL-C, but long-term real-world data in Japanese CAD patients are limited.
Does inclisiran reduce LDL-C levels in Japanese patients with coronary artery disease on maximally tolerated statin therapy?
Cohort (n=40)
Open-label
No
Does inclisiran reduce LDL-C levels in Japanese patients with coronary artery disease on maximally tolerated statin therapy?
In a real-world cohort of Japanese patients with CAD, inclisiran demonstrated a sustained reduction in LDL-C over 12 months with a favorable safety and tolerability profile.
Answers are grounded in this paper and cite their sources.
May support inclisiran for LDL-C reduction in Japanese CAD patients; extends trial data yet leaves open need for randomized confirmation.
Background: Clinical trial results suggest inclisiran lowers low-density lipoprotein-cholesterol (LDL-C), but long-term real-world data in Japanese coronary artery disease (CAD) patients are limited. Methods and Results: We retrospectively studied 40 CAD patients treated with inclisiran and followed for 12 months, assessing LDL-C levels at baseline and every 3 months; endpoints were within-patient LDL-C change, MACE (exploratory), and safety. Mean LDL-C fell by 59%, 56%, and 57% at 3, 6, and 12 months, respectively (all P<0.05). Adverse reactions comprised 1 case of MACE and 1 of injection-site reaction over the 12 months. Conclusions: In this single-center cohort, inclisiran was associated with sustained LDL-C reductions and acceptable tolerability over 1 year.
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Tsuda et al. (2026) conducted a cohort in Coronary artery disease (n=40). Inclisiran vs. Baseline was evaluated on Percent change in LDL-C levels from baseline to 12 months (57% reduction, p=<0.05). Inclisiran significantly reduced mean LDL-C levels by 57% over 12 months compared to baseline in patients with coronary artery disease.
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