Key result
Anterior and inferior MI show impaired RV function vs controls, with rapid 24-hour improvement.
Why the study?
The study was conducted to evaluate right ventricular function in patients presenting with their first myocardial infarction.
Does first myocardial infarction (inferior or anterior) affect right ventricular function compared to healthy controls?
Observational (n=70)
Does first myocardial infarction (inferior or anterior) affect right ventricular function compared to healthy controls?
p-value: p=<0.001
Right ventricular function is impaired in both inferior and anterior first myocardial infarctions due to ventricular interdependence, but shows rapid improvement within 24 hours.
Transient RV impairment after first MI does not alter acute management; leaves open need for prognostic validation in prospective cohorts.
Aim: The aim is to study the right ventricular (RV) function in patients of first myocardial infarction (MI). Methods: This study compared 25 patients of inferior wall MI (IWMI) with or without RVMI and 20 patients of anterior wall MI (AWMI) with 25 healthy age-matched controls. RV function was assessed using Tei index, tricuspid annular plane systolic excursion (TAPSE), tricuspid annular systolic (S'), early diastolic (E'), and late diastolic (A') velocities using tissue Doppler imaging (TDI) at first presentation and after 24 h. Results: In patients with IWMI, the Tei index was significantly increased (0.44 ± 0.09 vs. 0.22 ± 0.05; P < 0.001), TAPSE was reduced (1.25 ± 0.32 cm vs. 2.09 ± 0.26 cm; P < 0.001) and tricuspid annular S'(12.04 ± 1.74 cm/s vs. 16.48 ± 3.38 cm/s; P < 0.001) and E' (10.16 ± 2.23 cm/s vs. 12.32 ± 3.74 cm/s; P = 0.006) significantly decreased on TDI, compared to controls. Interestingly, patients with AWMI also had significantly increased Tei index (0.45 ± 0.16 vs. 0.22 ± 0.05; P < 0.001) and reduced TAPSE (1.52 ± 0.35 cm vs. 2.09 ± 0.26 cm; P < 0.001) and tricuspid annular S' (13.4 ± 2.5 cm/s vs. 16.48 ± 3.38 cm/s; P = 0.001) compared to controls. IWMI patients with associated RVMI had significantly reduced TAPSE (1.01 ± 0.24 cm vs. 1.43 ± 0.25 cm; P < 0.001) but did not differ with respect to the Tei index (0.42 ± 0.09 vs. 0.44 ± 0.09; P = 0.56) compared to those without ECG evidence of RVMI. Serial echocardiography showed significant improvements in measures of RV function. Conclusion: RV function is affected in all cases of MI, including AWMI, due to ventricular interaction and interdependence. Furthermore, RV function improves rapidly on follow-up.
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Prabhudesai et al. (2021) conducted an observational in First myocardial infarction (n=70). Echocardiographic assessment of RV function vs. Healthy age-matched controls was evaluated on Right ventricular function (Tei index, TAPSE, S', E') (p=<0.001). Right ventricular function was significantly impaired in both inferior and anterior wall MI compared to controls (e.g., Tei index 0.44 and 0.45 vs 0.22, P<0.001), with rapid improvement at 24 hours.
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