Key result
Interstitial fluid lipids in atherosclerotic intima, tumors, and adipose tissue promote lipid-loaded macrophage generation.
Why the study?
This study aimed to review and compare the roles of lipids and lipoproteins in shaping the inflammatory and lipid-enriched microenvironments of atherosclerotic arterial intima, malignant tumors, and obese adipose tissue, thereby generating dysfunctional macrophages.
This review highlights the shared mechanisms by which interstitial lipids and lipoproteins drive the formation of dysfunctional, lipid-loaded macrophages across atherosclerosis, cancer, and obesity.
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No immediate clinical implications; extends cross-disease evidence for lipid-driven macrophage phenotypes in atherosclerosis, cancer, and obesity.
Lee‐Rueckert et al. (2025) conducted a review in Atherosclerosis, cancer, and obesity. Lipids and lipoproteins in the interstitial fluids of atherosclerotic arterial intima, malignant tumors, and obese adipose tissue contribute to the generation of lipid-loaded macrophage subpopulations.
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