Key result
High-dose furosemide infusion causes unmeasurable serum creatinine concentrations with colorimetric methods, requiring the use of enzymatic methods in these patients.
Why the study?
Does high dose furosemide infusion interfere with colorimetric measurement of serum creatinine?
Does high dose furosemide infusion interfere with colorimetric measurement of serum creatinine?
High-dose furosemide infusion interferes with colorimetric serum creatinine measurement, necessitating the use of enzymatic methods.
Clinicians should confirm creatinine values with enzymatic assays during high-dose furosemide; this case report leaves open the interference frequency and impact.
Three patients had unmeasurable serum creatinine concentrations using a colorimetric method while receiving high doses of furosemide. The present study shows that enzymatic methods of measuring the serum creatinine concentration should be used in patients receiving high doses of furosemide.
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Murphy et al. (1989) studied this question. High-dose furosemide infusion causes unmeasurable serum creatinine concentrations with colorimetric methods, requiring the use of enzymatic methods in these patients.
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