Clinical Experience With Low-Dose Continuous Infusion of Furosemide in Acute Heart Failure

150 patients with acute heart failure, mean age 57 ± 13 years, 61% male, mean LVEF 37 ± 15% (28% preserved LVEF).

Furosemide administered as a low-dose (<160 mg/24 hours) continuous intravenous infusion (mean initial dose 5.1 ± 1.1 mg/h, maximum 6.2 ± 2.2 mg/h) for a mean duration of 51.4 ± 67.5 hours, after initial therapy with intermittent boluses.

Baseline therapy (intermittent boluses of furosemide, usually 40-80 mg every 12 hours).

Mean hourly urine output, incidence of acute renal injury, and outcome disparities of patients who developed acute renal injury.surrogate