Key result
Fasting blood glucose categories and insulin resistance were significantly related to left ventricular mass index (P=0.0002 in women, P=0.02 in men) and wall thickness in African Americans.
Why the study?
Are fasting blood glucose, diabetes, and insulin resistance associated with adverse left ventricular structure and function in African Americans?
Cohort (n=2,399)
Are fasting blood glucose, diabetes, and insulin resistance associated with adverse left ventricular structure and function in African Americans?
Fasting blood glucose levels and insulin resistance are significantly associated with adverse left ventricular structural and functional changes in African Americans.
Should not yet change practice; extends cross-sectional links between glycemia and LV mass in African Americans but leaves causality open.
OBJECTIVE We assessed the relation of diabetes and insulin resistance (IR) on left ventricular (LV) structure and function in African Americans. RESEARCH DESIGN AND METHODS Among those receiving echocardiograms in cycle 1 of the Jackson Heart Study, we assessed the sex-specific relation of fasting blood glucose (FBG), diabetes, and IR to LV structure and function, adjusting for age, systolic blood pressure, antihypertensive medications, and BMI. RESULTS Among 2,399 participants, LV mass index (Pwomen = 0.0002 and Pmen = 0.02), posterior wall thickness (Pwomen = 0.01 and Pmen = 0.05), and interventricular septal wall thickness (Pwomen = 0.01) were related to FBG categories. Among those with normal FBG and no diabetes, concentric remodeling and low ejection fraction in women and LV mass index and posterior wall thickness in men were related to IR. CONCLUSIONS In the largest study of its kind in a community-based cohort of African Americans, we found a relation of FBG category and IR to LV structure and function.
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Fox et al. (2011) conducted a cohort in Diabetes, impaired fasting blood glucose, and insulin resistance (n=2,399). Fasting blood glucose categories, diabetes, and insulin resistance vs. Normal fasting blood glucose and no diabetes was evaluated on Left ventricular structure and function (LV mass index, posterior wall thickness, interventricular septal wall thickness) (p=Pwomen = 0.0002 and Pmen = 0.02). Fasting blood glucose categories and insulin resistance were significantly related to left ventricular mass index (P=0.0002 in women, P=0.02 in men) and wall thickness in African Americans.
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