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This research aims to explore the expression of the human erythropoietin gene and its effect on red blood cell production.

Polycythemia in transgenic mice expressing the human erythropoietin gene.

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This research aims to explore the expression of the human erythropoietin gene and its effect on red blood cell production.
Human erythropoietin gene microinjected into fertilized mouse eggs to create transgenic mice.
Assessment of blood and tissue samples for erythrocytic indices and erythropoietin levels.
Comparison between transgenic homozygotes and heterozygotes for polycythemia severity.
Transgenic mice exhibited significant polycythemia with elevated erythrocytic indices in blood.
Increased erythroid precursor numbers were noted in hematopoietic tissue.
Homozygous transgenics displayed greater polycythemia and extramedullary erythropoiesis compared to heterozygous counterparts.

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Randomized trial demonstrates increased erythropoietin levels in transgenic mice, suggesting a new model for polycythemia.

Semenza et al. (1989) studied this question.

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