Key result
Intensive blood pressure control with valsartan significantly reduced the progression of urinary albumin excretion compared with moderate control in normotensive patients with type 2 diabetes (P=0.007).
Why the study?
Does intensive BP control with valsartan reduce urinary albumin excretion in normotensive patients with type 2 diabetes?
RCT (n=129)
Randomized
Does intensive BP control with valsartan reduce urinary albumin excretion in normotensive patients with type 2 diabetes?
p-value: p=0.007
Intensive BP control with valsartan significantly decreases the progression of urinary albumin excretion in normotensive patients with type 2 diabetes.
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Supports intensive valsartan-based BP control to slow albuminuria in normotensive T2DM; extends renoprotection evidence beyond hypertension.
Estacio et al. (2006) conducted an RCT in Type 2 diabetes without overt albuminuria (n=129). Intensive BP control (valsartan) vs. Moderate BP control (placebo initially, diastolic BP 80 to 90 mm Hg) was evaluated on Change in urinary albumin excretion (UAE) from baseline (p=0.007). Intensive blood pressure control with valsartan significantly reduced the progression of urinary albumin excretion compared with moderate control in normotensive patients with type 2 diabetes (P=0.007).
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