February 1, 1992Diabetes Care111 citations
View Full PaperLifetime Prevalence of Major Depression and Its Effect on Treatment Outcome in Obese Type II Diabetic Patients
Key Result
A history of major depression in obese type II diabetic patients was associated with higher treatment attrition (52.4% vs. 22.2%, P=0.03) but did not affect weight or glycemic improvements.
Study Design
Type
Cohort (n=66)
Structured PICO
Does a history of major depression affect treatment attrition and response to a 52-week behavioral weight-control program in obese patients with type II diabetes?
P
Population
66 obese subjects with type II diabetes (22 men, 44 women) seeking obesity treatment
I
Intervention
52-week behavioral weight-control program
C
Comparator
Subjects without a history of major depression
O
Outcome
Treatment attrition, weight, glycosylated hemoglobin, fasting blood glucose, and mood at 52 weeks
In obese patients with type II diabetes, a history of major depression increases the risk of dropping out of a behavioral weight-control program but does not impair the benefits for those who complete it.
Main Result
Absolute Event Rate: 52.4% vs 22.2%
p-value: p=0.03
Abstract
OBJECTIVE: To assess the lifetime prevalence of major depression (MD) and its relation to glycemic control among a group of non-insulin-dependent (type II) diabetic subjects seeking obesity treatment and to determine whether a history of MD affected response to treatment. RESEARCH DESIGN AND METHODS: Sixty-six obese subjects with type II diabetes (22 men, 44 women) completed the Inventory to Diagnose Depression-Lifetime Version before a 52-wk behavioral weight-control program. Weight, glycosylated hemoglobin, fasting blood glucose, and mood were assessed at pre- and posttreatment. RESULTS: Thirty-two percent of the subjects reported a history of MD. Neither a history of MD nor current depressive symptoms were associated with pretreatment glycemic control. However, a history of MD was related to treatment attrition (52.4 vs. 22.2%, P = 0.03). Subjects with and without a history of MD showed comparable improvements in weight, glycemic control, and mood. CONCLUSIONS: A history of MD among type II diabetic patients seeking obesity treatment was not related to pretreatment glycemic control but was associated with higher rates of attrition from treatment. Individuals with a history of MD who completed the program did not differ from those with no history of MD in response to treatment.