Key result
A history of major depression in obese type II diabetic patients was associated with higher treatment attrition (52.4% vs. 22.2%, P=0.03) but did not affect weight or glycemic improvements.
Why the study?
Does a history of major depression affect treatment attrition and response to a 52-week behavioral weight-control program in obese patients with type II diabetes?
Cohort (n=66)
Does a history of major depression affect treatment attrition and response to a 52-week behavioral weight-control program in obese patients with type II diabetes?
In obese patients with type II diabetes, a history of major depression increases the risk of dropping out of a behavioral weight-control program but does not impair the benefits for those who complete it.
Answers are grounded in this paper and cite their sources.
May warrant monitoring for attrition risk in obese diabetic patients with depression history; hypothesis-generating for retention strategies in trials.
OBJECTIVE: To assess the lifetime prevalence of major depression (MD) and its relation to glycemic control among a group of non-insulin-dependent (type II) diabetic subjects seeking obesity treatment and to determine whether a history of MD affected response to treatment. RESEARCH DESIGN AND METHODS: Sixty-six obese subjects with type II diabetes (22 men, 44 women) completed the Inventory to Diagnose Depression-Lifetime Version before a 52-wk behavioral weight-control program. Weight, glycosylated hemoglobin, fasting blood glucose, and mood were assessed at pre- and posttreatment. RESULTS: Thirty-two percent of the subjects reported a history of MD. Neither a history of MD nor current depressive symptoms were associated with pretreatment glycemic control. However, a history of MD was related to treatment attrition (52.4 vs. 22.2%, P = 0.03). Subjects with and without a history of MD showed comparable improvements in weight, glycemic control, and mood. CONCLUSIONS: A history of MD among type II diabetic patients seeking obesity treatment was not related to pretreatment glycemic control but was associated with higher rates of attrition from treatment. Individuals with a history of MD who completed the program did not differ from those with no history of MD in response to treatment.
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Marcus et al. (1992) conducted a cohort in Obese type II diabetes (n=66). History of major depression vs. No history of major depression was evaluated on Treatment attrition (p=0.03). A history of major depression in obese type II diabetic patients was associated with higher treatment attrition (52.4% vs. 22.2%, P=0.03) but did not affect weight or glycemic improvements.
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