A further refinement of the recently reported IMPEACH-MBC long-range heteronuclear shift correlation experiment is described. The new experiment, CIGAR-HMBC (constant time inverse-detected gradient accordion rescaled long-range heteronuclear multiple bond correlation), modifies the constant time variable delay of the IMPEACH-MBC experiment to allow user-determined scaling of F1 modulation. The refinement offered in the CIGAR-HMBC experiment allows the investigator to reintroduce whatever degree of F1 modulation is desired to authenticate weak long-range responses. Results obtained with the CIGAR-HMBC experiment using a range of values for Jscale are compared with results obtained with identically optimized ACCORD-HMBC and IMPEACH-MBC experiments.
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Hadden et al. (2000) studied this question.
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