Clonal hematopoiesis, with and without candidate driver mutations, is common in the elderly

Florian Zink; Simon Stacey; Gudmundur L. Norddahl; Michael L. Frigge; Ólafur Þ. Magnússon; Ingileif Jónsdóttir; Thorgeir E. Thorgeirsson; Ásgeir Sigurðsson; Sigurjón A. Guðjónsson; Jūlı́us Guðmundsson; Jón G. Jónasson; Laufey Tryggvadóttír; Þorvaldur Jónsson; Agnar Helgason; Arnaldur Gylfason; Patrick Sulem; Þórunn Rafnar; Unnur Þorsteinsdóttir; Daníel F. Guðbjartsson; Gísli Másson; Augustine Kong; Kāri Stefánsson

doi:10.1182/blood-2017-02-769869

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Abstract

Key Points Whole-genome sequencing of 11 262 Icelanders reveals that clonal hematopoiesis is very common in the elderly. Somatic mutation of some genes is strongly associated with clonal hematopoiesis, but in most cases, no driver mutations were evident.

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synapsesocial.com/papers/6a0e3135358c8502d7d09d7f https://doi.org/10.1182/blood-2017-02-769869

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Clonal hematopoiesis, with and without candidate driver mutations, is common in the elderly

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Abstract

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Cite This Study

Clonal hematopoiesis, with and without candidate driver mutations, is common in the elderly

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Abstract

Discussion

Cite This Study

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