Using the regression model proposed by Cox (1972) a test for monotone trend in hazard functions is derived for use, for example, in chemical carcinogenesis experiments in which a chemical is administered at increasing dose levels. It is demonstrated that under the null hypothesis of no dose-response relationship the test statistic is distributed asymptotically as chi-squared with one degree of freedom. An exact test for trend is proposed which is valid when censorship is random and equal.
No takes yet. Share an insight, caveat, or question.
Robert E. Tarone (1975) studied this question.
Synapse has enriched 5 related papers. Consider them for comparative context: