Prediction of the Secondary Structure of Proteins from their Amino Acid Sequence

Peter Y. Chou; Gerald D. Fasman

doi:10.1002/9780470122921.ch2

January 1, 1979

Prediction of the Secondary Structure of Proteins from their Amino Acid Sequence

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Key Points

To review the theoretical principles, conformational parameters, and computational implementations of the Chou and Fasman method for predicting protein secondary structures from primary amino acid sequences.
Delineation of conformational regions and empirical assignment of conformational parameters to individual amino acid residues.
Application of predictive heuristics to determine alpha-helical, beta-sheet, and coil conformations along polypeptide chains.
Comparative analysis of manual and computerized secondary structure prediction algorithms against alternative computational methods.
Established predictive rules and statistical propensities linking specific amino acid residues to localized secondary structure formations.
Demonstrated the feasibility of automated, computerized Chou-Fasman implementations for rapid secondary structure assignment from linear sequences.

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Implication

Methodological review demonstrates predictive secondary structure modeling in amino acid sequences, highlighting the computerized Chou-Fasman algorithm.

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Chou et al. (1979) studied this question.

synapsesocial.com/papers/6a0e4c5e54773662f7594344 https://doi.org/10.1002/9780470122921.ch2

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Prediction of the Secondary Structure of Proteins from their Amino Acid Sequence

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Prediction of the Secondary Structure of Proteins from their Amino Acid Sequence

Key Points

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Implication

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