Key result
Initial platelet accumulation in mice reduces local transport to drive thrombin buildup and further platelet activation.
Population
Mice (including Sema4D deleted models)
Design
Preclinical
Authors
Loading...
Informs experimental models of thrombus formation; leaves open applicability to human disease.
Platelet accumulation creates a microenvironment with reduced transport that facilitates local thrombin accumulation and shapes thrombus architecture.
Welsh et al. (2014) studied Hemostasis and thrombus formation. Sema4D deletion was evaluated on Intrathrombus transport rates, agonist distribution, and platelet activation. In mice, initial platelet accumulation created a region of reduced transport that facilitated local thrombin accumulation and greater platelet activation, shaping thrombus architecture.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: