Key result
Early repolarization pattern linked to differences in 22 ECG parameters in healthy young males.
Why the study?
Early repolarization pattern has recently been linked to an increased risk of ventricular arrhythmias in susceptible individuals, prompting investigation into ERP-associated ECG changes with potential clinical relevance.
Does early repolarization pattern associate with specific ECG changes in healthy young males?
Cross-Sectional (n=220)
Does early repolarization pattern associate with specific ECG changes in healthy young males?
In healthy young males, the early repolarization pattern is associated with specific ECG changes, such as altered P wave duration and fragmented QRS complexes, which may reflect a propensity for arrhythmogenesis.
Does not warrant practice changes in healthy males; leaves open whether early repolarization links to arrhythmogenic ECG features.
Background and Objectives: Early repolarization pattern (ERP) has recently been shown to be related with an increased risk of ventricular arrhythmias in susceptible individuals. Materials and Methods: We studied the ERP-associated ECG changes, with potential clinical relevance, in 220 young (age 22.1 ± 1.6 years), healthy, male subjects using 12-lead ECG recordings. A total of 38 subjects (17.3%) fulfilled the diagnostic criteria for ERP, and a total of 90 ECG characteristics were compared between the groups of subjects with and without ERP. Results: None of the ECGs were pathological, and 22 ECG parameters differed significantly (p < 0.05) between the subjects with and without ERP. Among them, the P wave-related parameters (e.g., average P wave duration: 101.5 ± 9.2 ms vs. 106.8 ± 9.9 ms, p = 0.004) and the presence of fragmented QRS complexes (67.6% vs. 92.1%, p = 0.002) revealed a potential propensity for atrial and ventricular arrhythmogenesis. The time-domain parameters of repolarization, those not corrected for QRS duration, showed shorter values (e.g., Tpeak-Tend interval: 70.9 ± 8.1 ms vs. 67.8 ± 8.0 ms, p = 0.036), reflecting the accelerated repolarization. Conclusions: Certain ECG characteristics seem to be more associated with ERP. The clinical significance of this finding at the individual level needs further prospective investigations.
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Frigy et al. (2022) conducted a cross-sectional in Healthy young males (n=220). Early repolarization pattern (ERP) vs. Without ERP was evaluated on ECG characteristics (90 parameters). Early repolarization pattern in healthy young males was associated with significant differences in 22 ECG parameters, including the presence of fragmented QRS complexes (67.6% vs. 92.1%, p=0.002).
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