Key result
CMRI-derived pulmonary artery distensibility <20% predicted poor functional capacity (<400m in 6-minute walk test) with 82% sensitivity and 94% specificity in patients with PAH.
Why the study?
Does CMRI-derived pulmonary artery distensibility index correlate with invasive pulmonary artery stiffness and predict functional capacity in patients with pulmonary arterial hypertension?
Observational (n=35)
Does CMRI-derived pulmonary artery distensibility index correlate with invasive pulmonary artery stiffness and predict functional capacity in patients with pulmonary arterial hypertension?
Effect estimate: R²=0.61
p-value: p=<0.001
Non-invasive CMRI-derived pulmonary artery distensibility correlates well with invasive hemodynamics and strongly predicts functional capacity in patients with pulmonary arterial hypertension.
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May support non-invasive PAH risk stratification via CMRI; leaves open prospective validation and outcome impact.
Kang et al. (2011) conducted an observational in Pulmonary arterial hypertension (PAH) (n=35). Cardiac magnetic resonance imaging (CMRI)-derived PA distensibility index vs. Right heart catheterization (RHC) was evaluated on Correlation of PA distensibility with PVR, PA capacitance, and 6MWT distance (R²=0.61, p=<0.001). CMRI-derived pulmonary artery distensibility <20% predicted poor functional capacity (<400m in 6-minute walk test) with 82% sensitivity and 94% specificity in patients with PAH.
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