What question did this study set out to answer?

To determine whether circulating plasma levels of immunoreactive adrenomedullin provide independent prognostic value in patients with chronic heart failure.

June 15, 2000European Heart JournalOpen Access

Plasma adrenomedullin, a new independent predictor of prognosis in patients with chronic heart failure

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Why the study?

Are elevated plasma levels of immunoreactive adrenomedullin an independent predictor of prognosis in patients with chronic heart failure?

Population

117 chronic heart failure patients with idiopathic or ischaemic cardiomyopathy, treated with ACE inhibitors…

Design

Cohort

Follow-up

237 +/- 137 days

Authors

FPFrançoise PoussetSorbonne Université

Discussion

Member takes

Implication

Adrenomedullin levels may aid prognosis in chronic HF; leaves open incremental value beyond endothelin-1 and SBP.

Key Points

To determine whether circulating plasma levels of immunoreactive adrenomedullin provide independent prognostic value in patients with chronic heart failure.
Prospective evaluation of 117 patients with chronic heart failure (idiopathic or ischaemic cardiomyopathy, mean ejection fraction 28 ± 10%, NYHA class I–IV) receiving ACE inhibitors and diuretics.
Plasma immunoreactive adrenomedullin was measured via radioimmunoassay and compared with healthy controls.
Patients were monitored over a mean follow-up period of 237 ± 137 days, with prognostic associations assessed via univariate and multivariate Cox proportional hazards models.
Plasma immunoreactive adrenomedullin levels were significantly higher in heart failure patients than in controls (618 ± 293 pg/ml vs 480 ± 135 pg/ml, P=0.01).
During follow-up, 14 cardiovascular deaths and 4 urgent heart transplantations occurred, with adrenomedullin predicting adverse outcomes in univariate analysis (P=0.004).
Multivariate analysis established plasma adrenomedullin (P=0.03), endothelin-1 (P=0.0001), and systolic blood pressure (P=0.003) as independent predictors of patient outcome.

Structured PICO

Are elevated plasma levels of immunoreactive adrenomedullin an independent predictor of prognosis in patients with chronic heart failure?

Population

117 chronic heart failure patients with idiopathic or ischaemic cardiomyopathy (mean ejection fraction: 28 +/- 10%, NYHA functional class I/II/III/IV: 8/73/29/7), treated with ACE inhibitors and diuretics.

Intervention

Plasma levels of immunoreactive adrenomedullin (ir-ADM)

Outcome

Composite of cardiovascular death and urgent cardiac transplantationhard clinical

Elevated plasma levels of immunoreactive adrenomedullin serve as an independent predictor of adverse prognosis in patients with mild to moderate chronic heart failure.

Cite This Study

Françoise Pousset (2000) studied this question.

synapsesocial.com/papers/6a0e4e53bc348c84f2fd9a9e https://doi.org/10.1053/euhj.1999.1904

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Plasma adrenomedullin, a new independent predictor of prognosis in patients with chronic heart failure

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Plasma adrenomedullin, a new independent predictor of prognosis in patients with chronic heart failure

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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