Key result
Review outlines how the genetics of cardiac fatty tissue contribute to ventricular arrhythmias.
Why the study?
Cardiac fatty tissue may serve as an arrhythmogenic substrate, but diagnosing it remains challenging and data on the influence of genetic variants on epicardial adipose tissue volume are limited.
This review highlights the potential role of cardiac fatty tissue as a substrate for ventricular arrhythmias and explores the genetic variants influencing epicardial adipose tissue.
Answers are grounded in this paper and cite their sources.
Cardiac fat genetics warrant no practice change; leaves open hypothesis-generating research on arrhythmia substrates.
Ventricular arrhythmias are a common disorder, and sometimes the etiology remains unclear. Present data support cardiac fatty tissue’s potential role as a substrate for ventricular arrhythmias. Diagnosing fatty tissue based on imaging markers and histopathological evidence is often challenging. Data about the influence of individual and multiple genetic variants on epicardial adipose tissue volume remain limited. In this review, we aimed to provide a comprehensive overview of the current understanding of the genetic basis of fatty tissue and its contribution to the pathogenesis of ventricular arrhythmias and to discuss the relationship between certain genetic variants and the development of ventricular arrhythmia.
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Prisecaru et al. (2025) conducted a review in Ventricular arrhythmias. This review summarizes the current understanding of the genetic basis of cardiac fatty tissue and its contribution to the pathogenesis and development of ventricular arrhythmias.
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