Key result
X-ray structural analysis of foot-and-mouth disease virus polymerase 3D complexes identified key amino acid interactions that explain the molecular basis of low viral RNA replication fidelity.
Population
Foot-and-mouth disease virus polymerase 3D elongation complexes with different RNAs as template-primer…
Design
Preclinical
Authors
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Structural insights into FMDV polymerase fidelity may guide mutagenic antivirals; leaves open clinical translation from animal data.
X-ray crystallography of FMDV polymerase 3D reveals the structural basis for nucleotide recognition and the low fidelity of viral RNA polymerases, providing insights for the design of antiviral mutagenic nucleotides.
Ferrer‐Orta et al. (2007) studied Foot-and-mouth disease virus. Mutagenic nucleotides (ribavirin triphosphate and 5-fluorouridine triphosphate) vs. Natural substrates (ATP and UTP) was evaluated on X-ray structure of elongation complexes and critical amino acid interactions. X-ray structural analysis of foot-and-mouth disease virus polymerase 3D complexes identified key amino acid interactions that explain the molecular basis of low viral RNA replication fidelity.
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