Key result
Ribavirin significantly decreased hMPV replication in lungs by 5 log10 and global pulmonary inflammation on day 5 postinfection, whereas glucocorticoids reduced only alveolar and interstitial inflammation.
Why the study?
Does ribavirin and/or corticosterone reduce viral replication and pulmonary inflammation in a mouse model of hMPV infection?
Population
48 4- to 6-week-old BALB/c mice (32 infected intranasally with hMPV, 16 sham-infected)
Comparison
Ribavirin, corticosterone, or both vs Phosphate-buffered saline for infected mice, and…
Design
Preclinical, Randomized into six groups of eight mice each, based on weight
Follow-up
5 days
Authors
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Supports advancing ribavirin to human hMPV trials; leaves open glucocorticoid role pending clinical studies.
Does ribavirin and/or corticosterone reduce viral replication and pulmonary inflammation in a mouse model of hMPV infection?
In a mouse model of human metapneumovirus infection, ribavirin significantly decreased viral replication and pulmonary inflammation, while glucocorticoids had a modest effect on specific types of inflammation.
Hamelin et al. (2006) studied Human metapneumovirus (hMPV) infection. Ribavirin and/or corticosterone vs. Controls was evaluated on hMPV replication in lungs and pulmonary inflammation. Ribavirin significantly decreased hMPV replication in lungs by 5 log10 and global pulmonary inflammation on day 5 postinfection, whereas glucocorticoids reduced only alveolar and interstitial inflammation.
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