Ribavirin significantly decreased hMPV replication in lungs by 5 log10 and global pulmonary inflammation on day 5 postinfection, whereas glucocorticoids reduced only alveolar and interstitial inflammation.
Does ribavirin and/or corticosterone reduce viral replication and pulmonary inflammation in a mouse model of hMPV infection?
In a mouse model of human metapneumovirus infection, ribavirin significantly decreased viral replication and pulmonary inflammation, while glucocorticoids had a modest effect on specific types of inflammation.
Human metapneumovirus (hMPV)-infected BALB/c mice were treated with ribavirin (40 mg/kg of body weight twice a day intraperitoneally), corticosterone (0.2 mg/ml in water), or both modalities. Ribavirin significantly decreased both hMPV replication in lungs (by 5 log10) and global pulmonary inflammation on day 5 postinfection, whereas glucocorticoids reduced only alveolar and interstitial inflammation, compared to controls.
Hamelin et al. (Wed,) conducted a other in Human metapneumovirus (hMPV) infection. Ribavirin and/or corticosterone vs. Controls was evaluated on hMPV replication in lungs and pulmonary inflammation. Ribavirin significantly decreased hMPV replication in lungs by 5 log10 and global pulmonary inflammation on day 5 postinfection, whereas glucocorticoids reduced only alveolar and interstitial inflammation.
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