What is the clinical evidence from this study?

Study design: Cohort. Population: Apical hypertrophic cardiomyopathy (AHCM) (n=11). Primary outcome: Apical muscle cross-sectional area (AMA) change over time (p=ns).

What question did this study set out to answer?

To quantitatively evaluate the severity and progression of apical left ventricular hypertrophy, assess its correlation with electrocardiographic abnormalities, and examine long-term clinical outcomes.

February 1, 1995European Heart Journal

Long-term evaluation of patients with apical hypertrophic cardiomyopathy

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Key result

Long-term follow-up of apical hypertrophic cardiomyopathy revealed no significant progression in apical muscle cross-sectional area (13.2 to 13.8 cm2) despite worsening ECG findings.

Population

11 patients with apical hypertrophic cardiomyopathy, 7 men and 4 women, mean age 49.

Design

Cohort, four independent and blinded observers

Follow-up

average 6 year

Authors

EME MoroTianjin University GDGianluca A D’AngeloUniversità Cattolica del Sacro Cuore GNGian Luigi NicolosiCardiac Imaging

Discussion

Member takes

Implication

Worsening ECGs in apical HCM may not indicate progression; leaves open need for imaging-guided monitoring in longitudinal cohorts.

Key Points

To quantitatively evaluate the severity and progression of apical left ventricular hypertrophy, assess its correlation with electrocardiographic abnormalities, and examine long-term clinical outcomes.
Followed 11 patients with apical hypertrophic cardiomyopathy (7 men, 4 women; age range 18–62 years, mean 49 years) over an average follow-up period of 6 years.
Quantified apical muscle cross-sectional area as an index of myocardial mass using digitized end-diastolic apical four-chamber echocardiograms averaged across four blinded observers.
Precordial negative T-wave amplitude increased from 8.5 ± 3.4 mm to 11.9 ± 3.6 mm during follow-up, while precordial R-wave voltage showed a non-significant rise from 28.0 ± 5.9 mm to 29.3 ± 5.2 mm.
Apical muscle cross-sectional area showed no significant progression over time, changing from 13.2 ± 2.6 cm² to 13.8 ± 2.3 cm².
All 11 patients remained alive at final follow-up without significant symptomatic deterioration, demonstrating that electrocardiographic worsening does not correlate with functional decline.

Study Design

Type

Cohort (n=11)

Blinding

Blinded observers

Structured PICO

Population

11 patients with apical hypertrophic cardiomyopathy (AHCM), 7 men and 4 women, mean age 49 (range 18 to 62 years).

Outcome

Changes in echocardiographic and ECG parameters over time, and the relationship between the severity of AHCM and clinical coursesurrogate

Main Result

p-value: p=ns

In patients with apical hypertrophic cardiomyopathy, ECG findings may worsen over time without significant progression in apical wall thickness or clinical symptomatic deterioration.

Cite This Study

Moro et al. (1995) conducted a cohort in Apical hypertrophic cardiomyopathy (AHCM) (n=11). Long-term follow-up of apical hypertrophic cardiomyopathy revealed no significant progression in apical muscle cross-sectional area (13.2 to 13.8 cm2) despite worsening ECG findings.

synapsesocial.com/papers/6a0e4e8abc348c84f2fd9b18 https://doi.org/10.1093/oxfordjournals.eurheartj.a060887

Topics

Echocardiography Hypertrophic cardiomyopathy

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Long-term evaluation of patients with apical hypertrophic cardiomyopathy

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Topics

Long-term evaluation of patients with apical hypertrophic cardiomyopathy

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Also Consider

Topics

Also Consider