Why the study?
Does late reperfusion of infarct-related arteries benefit patients with acute myocardial infarction who present too late for myocardial salvage?
Does late reperfusion of infarct-related arteries benefit patients with acute myocardial infarction who present too late for myocardial salvage?
This review summarizes the clinical and experimental evidence supporting the open artery hypothesis, which suggests that late reperfusion of infarct-related arteries provides benefits beyond myocardial salvage, such as preventing infarct expansion and reducing ventricular remodeling.
There is considerable clinical and experimental evidence of the benefit of late reperfusion of infarct-related arteries, referred to as the open artery hypothesis, in patients with acute myocardial infarction who presented too late to salvage at-risk ischemic myocardium. In addition to myocardial salvage, reperfusion of the infarct-related artery prevents infarct expansion, reduces development of ventricular remodeling, and decreases ventricular arrhythmia. The Occluded Artery Trial recently answered a major question related to the open artery hypothesis in a high-risk, asymptomatic patient with an occluded infarct artery. In this review, clinical and experimental evidence of the benefit of the open artery hypothesis will be discussed. (Korean Circulation J 2007;37:235-243)
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Chul-Min Kim (2007) conducted a review in Acute myocardial infarction. Late reperfusion (Percutaneous Coronary Intervention) vs. Optimal medical therapy was evaluated.
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