Elevated Lipoprotein(a) levels (≥75 nmol/L) were associated with increased aortic valve microcalcification assessed by 18F-sodium fluoride PET/CT in individuals without clinical CAVS (P=0.02).
Observational (n=551)
Yes
Does elevated Lipoprotein(a) predict aortic valve microcalcification in individuals without clinically manifested calcific aortic valve stenosis?
Elevated Lipoprotein(a) is associated with early aortic valve microcalcification detectable by 18F-NaF PET/CT prior to the development of clinical calcific aortic valve stenosis.
p-value: p=0.02
BACKGROUND: Lipoprotein(a) (Lpa) is the preferential lipoprotein carrier of oxidized phospholipids (OxPLs) and a well-established genetic risk factor for calcific aortic valve stenosis (CAVS). Whether Lp(a) predicts aortic valve microcalcification in individuals without CAVS is unknown. Our objective was to estimate the prevalence of elevated Lp(a) and OxPL levels in patients with CAVS and to determine if individuals with elevated Lp(a) but without CAVS have higher aortic valve microcalcification. METHODS: We recruited 214 patients with CAVS from Montreal and 174 patients with CAVS and 108 controls from Québec City, Canada. In a second group of individuals with high (≥75 nmol/L, n = 27) or low (<75 nmol/L, n = 28) Lp(a) levels, 18F-sodium fluoride positron emission tomography/computed tomography was performed to determine the difference in mean tissue-to-background ratio (TBR) of the aortic valve. RESULTS: = 0.02). CONCLUSIONS: Elevated Lp(a) and OxPL levels are associated with prevalent CAVS in patients studied in an echocardiography laboratory setting. In individuals with elevated Lp(a), evidence of aortic valve microcalcification by 18F-sodium fluoride positron emission tomography/computed tomography is present before the development of clinically manifested CAVS.
Després et al. (Fri,) conducted a observational in Calcific aortic valve stenosis (n=551). Elevated Lipoprotein(a) (≥75 nmol/L) vs. Low Lipoprotein(a) (<75 nmol/L) was evaluated on Difference in mean tissue-to-background ratio (TBR) of the aortic valve by 18F-sodium fluoride PET/CT (p=0.02). Elevated Lipoprotein(a) levels (≥75 nmol/L) were associated with increased aortic valve microcalcification assessed by 18F-sodium fluoride PET/CT in individuals without clinical CAVS (P=0.02).