Key result
Candesartan significantly reduced the percent increase in left ventricular end-diastolic volume index to 5.3% compared to 17.2% with ACE inhibitors at 6 months after acute myocardial infarction.
Why the study?
Does candesartan improve left ventricular remodeling in post-AMI patients compared to ACE inhibitors?
RCT (n=160)
Open-label with blinded endpoint evaluation
Envelope method
No
Does candesartan improve left ventricular remodeling in post-AMI patients compared to ACE inhibitors?
Candesartan may be more effective than ACE inhibitors in preventing left ventricular remodeling after acute myocardial infarction.
Answers are grounded in this paper and cite their sources.
May suggest candesartan advantage for post-AMI remodeling; leaves open confirmation in randomized trials.
Although angiotensin-converting enzyme inhibitors (ACEIs) have been shown to reduce left ventricular remodeling after acute myocardial infarction (AMI), the effects of angiotensin receptor blockers have yet to be established. This study was conducted to examine the effects of candesartan on left ventricular remodeling after AMI. Consecutive AMI patients were assigned to a candesartan group or ACEI group after successful coronary intervention. The patients in the candesartan group (n = 77, mean age, 62.8 +/- 1.3) received candesartan and the patients in the ACEI group (n = 80, mean age, 63.3 +/- 1.2) received lisinopril, enalapril, or trandolapril. Four mg was the most frequent dose in the candesartan group at 6 months. Lisinopril, enalapril, and trandolapril were administered to 52%, 27%, and 21% of the patients in the ACEI group, respectively. No significant differences in the incidences of cardiac death, nonfatal MI, or hospitalization for heart failure (P = NS) were found between the groups. The candesartan group exhibited a somewhat higher percent increase in left ventricular ejection fraction and significantly lower percent increases in left ventricular end-diastolic volume index and left ventricular end-systolic volume index compared to the ACEI group (P < 0.05, P < 0.05, respectively). Candesartan is more effective than ACEI in preventing left ventricular remodeling after AMI.
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Suzuki et al. (2006) conducted an RCT in Acute Myocardial Infarction (n=160). Candesartan cilexetil vs. ACE inhibitors (lisinopril, enalapril, or trandolapril) was evaluated on Percent increase in left ventricular end-diastolic volume index (LVEDVI) (p=<0.05). Candesartan significantly reduced the percent increase in left ventricular end-diastolic volume index to 5.3% compared to 17.2% with ACE inhibitors at 6 months after acute myocardial infarction.
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