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October 24, 2006CirculationOpen Access

Pretreatment With Angiotensin Receptor Blockade Prevents Left Ventricular Dysfunction and Blunts Left Ventricular Remodeling Associated With Acute Myocardial Infarction

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Why the study?

Does pretreatment with candesartan improve left ventricular function and remodeling during acute myocardial infarction in Sprague-Dawley rats?

Population

Sprague-Dawley rats with acute myocardial infarction

Comparison

Candesartan (10 mg/kg/d) for 2 weeks prior to MI vs Untreated rats

Design

Preclinical

Follow-up

1, 3, and 6 minutes after MI

Authors

HTHoang ThaiUniversity of ArizonaLCL. CastellanoUniversity of ArizonaEJElizabeth JunemanUniversity of Arizona

Discussion

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Implication

Should not change clinical practice; hypothesis-generating for candesartan pretreatment in experimental MI.

Structured PICO

Does pretreatment with candesartan improve left ventricular function and remodeling during acute myocardial infarction in Sprague-Dawley rats?

P
Population
Sprague-Dawley rats with acute myocardial infarction
I
Intervention
Candesartan (10 mg/kg/d) for 2 weeks prior to MI
C
Comparator
Untreated rats
O
Outcome
Left ventricular function and remodeling (LV systolic pressure, LV fractional shortening, ejection fraction, LV chamber dilation, LV endothelial nitric oxide synthase, constitutive microtubulin) at 1, 3, and 6 minutes after MIsurrogate

Pretreatment with candesartan before acute MI improves global LV function and attenuates LV remodeling in a rat model.

Cite This Study

Thai et al. (2006) studied this question.

synapsesocial.com/papers/6a0e8fdfa0467873efc842cfhttps://doi.org/10.1161/circulationaha.106.653329
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