Key result
Ablation site diastolic potentials linked to ~15-fold greater odds of acute success for RVOT PVCs.
Why the study?
Discrete potentials, low voltage, and fragmented electrograms had been reported at RVOT ablation sites, but the presence of diastolic potentials and their association with ablation success needed assessment.
Does the presence of isolated diastolic potentials at the ablation site predict acute success in radiofrequency ablation of idiopathic RVOT PVCs?
Observational (n=48)
Yes
Does the presence of isolated diastolic potentials at the ablation site predict acute success in radiofrequency ablation of idiopathic RVOT PVCs?
Diastolic potentials were associated with acute ablation success in RVOT PVCs; leaves open prospective validation before guiding mapping strategies.
BACKGROUND AND AIMS: Discrete potentials, low voltage and fragmented electrograms, have been previously reported at ablation site, in patients with premature ventricular contractions (PVCs) originating in the right ventricular outflow tract (RVOT). The aim of this study was to review the electrograms at ablation site and assess the presence of diastolic potentials and their association with success. METHODS: We retrospectively reviewed the electrograms obtained at the radiofrequency (RF) delivery sites of 48 patients subjected to ablation of RVOT frequent PVCs. We assessed the duration and amplitude of local electrogram, local activation time, and presence of diastolic potentials and fragmented electrograms. RESULTS: We reviewed 134 electrograms, median 2 (1-4) per patient. Success was achieved in 40 patients (83%). At successful sites the local activation time was earlier- 54 (-35 to -77) ms vs -26 (-12 to -35) ms, p<0.0001; the local electrogram had lower amplitude 1 (0.45-1.15) vs 1.5 (0.5-2.1) mV, p = 0.006, and longer duration 106 (80-154) vs 74 (60-90) ms, p<0.0001. Diastolic potentials and fragmented electrograms were more frequently present, respectively 76% vs 9%, p <0.0001 and 54% vs 11%, p<0.0001. In univariable analysis these variables were all associated with success. In multivariable analysis only the presence of diastolic potentials [OR 15.5 (95% CI: 3.92-61.2; p<0.0001)], and the value of local activation time [OR 1.11 (95% CI: 1.049-1.172 p<0.0001)], were significantly associated with success. CONCLUSION: In this group of patients the presence of diastolic potentials at the ablation site was associated with success.
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Parreira et al. (2019) conducted an observational in Idiopathic right ventricular outflow tract premature ventricular contractions (n=48). Presence of diastolic potentials at ablation site vs. Absence of diastolic potentials at ablation site was evaluated on Acute success of ablation (OR 15.5, 95% CI 3.92-61.2, p=<0.0001). The presence of diastolic potentials at the ablation site significantly increased the odds of acute success (OR 15.5) for right ventricular outflow tract premature ventricular contractions.
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