Key result
Truncated myosin VI constructs lacking the unique insert generated (+)-end-directed motion, demonstrating that the unique insert is required for directionality reversal.
Population
In vitro models using truncated porcine myosin VI constructs
Comparison
Truncation of myosin VI at four different… vs Comparison among different truncation lengths
Design
Preclinical
Authors
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No immediate clinical implications; leaves open myosin VI's role in human cardiac motility for future studies.
Experimental mapping of myosin VI constructs demonstrates that its unique insert is required for directionality reversal, driven by an ~180 degree rotation of the lever arm.
Bryant et al. (2006) studied this question. Truncated myosin VI constructs was evaluated on Direction and size of the power stroke. Truncated myosin VI constructs lacking the unique insert generated (+)-end-directed motion, demonstrating that the unique insert is required for directionality reversal.
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