Why the study?
Does mechanical stretch induce nonuniform Ca2+ sensitization and VLC2b phosphorylation across the ventricular wall in normal and post-myocardial infarcted rat hearts?
Population
Left ventricular skinned rat myocytes from normal and post-myocardial infarcted rats
Comparison
Mechanical stretch vs Unstretched state, sub-epicardium vs…
Design
Preclinical
Authors
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May contribute to post-MI LV impairment in rats; hypothesis-generating for transmural mechanics in human HF.
Does mechanical stretch induce nonuniform Ca2+ sensitization and VLC2b phosphorylation across the ventricular wall in normal and post-myocardial infarcted rat hearts?
The loss of a contractile transmural gradient and stretch-dependent VLC2b phosphorylation after myocardial infarction may contribute to impaired left ventricular function.
Cazorla et al. (2004) studied this question.
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