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We demonstrate the first three-input molecular AND logic gate based on three chemical inputs as a direct way of detecting congregations of chemical species. The AND gate operates in water and responds to Na+, H+, and Zn2+ inputs with an enhanced fluorescence signal when pre-set concentration thresholds are exceeded. Future "lab-on-a-molecule" devices could have application in medicine for rapid disease screening.
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Magri et al. (2006) studied this question.
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