Key result
Dietary bioactive compounds target central pathways and oxidative stress to mitigate salt-sensitive hypertension.
Why the study?
Existing studies lack a comprehensive analysis integrating multiple central nervous system and cellular mechanisms with systematic summaries of dietary bioactive compounds and clinical translation in salt-sensitive hypertension.
Do dietary bioactive compounds and targeted central nervous system interventions modulate pathophysiological mechanisms to reduce arterial blood pressure in salt-sensitive hypertension?
Do dietary bioactive compounds and targeted central nervous system interventions modulate pathophysiological mechanisms to reduce arterial blood pressure in salt-sensitive hypertension?
This review delineates the central nervous system mechanisms driving salt-sensitive hypertension and highlights the therapeutic potential of dietary bioactive compounds in targeting these complex regulatory networks.
Hypothesis-generating for dietary bioactives in salt-sensitive hypertension; extends mechanistic framework but leaves open randomized validation.
Salt-sensitive hypertension (SSH) is an important and common subtype of hypertension, whose pathogenesis involves multi-level regulation, including the central nervous system (CNS), metabolic stress, and epigenetics. Dietary bioactive compounds have emerged as a research hotspot for SSH intervention due to their safety and multi-target effects. Although existing studies have focused on the CNS regulation of SSH or the role of individual dietary components, there is a lack of comprehensive analysis integrating multiple mechanisms, systematically summarizing multiple compounds, and incorporating a clinical translation perspective. This review first outlines the mechanisms of CNS pathways, endoplasmic reticulum (ER) stress, mitochondrial dysfunction, and epigenetic modifications in SSH. Then, it systematically reviews the mechanisms of action and preclinical and clinical research progress of bioactive compounds, including capsaicin, taurine, gamma-aminobutyric acid, tea, and anthocyanins in SSH. In summary, this review systematically clarifies the complex regulatory network of SSH and the intervention potential of dietary bioactive compounds from an integrated perspective, innovatively proposes a precise dietary intervention framework, and fills the research gaps in the integration of multiple mechanisms and systematic evaluation of compounds in existing studies. This framework not only provides a new integrated perspective for the basic research of SSH but also offers key references for clinical dietary guidance, functional food development, and the formulation of targeted intervention strategies.
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Wang et al. (2025) conducted a review in Salt-sensitive hypertension (SSH). Dietary bioactive compounds (capsaicin, taurine, GABA, tea, anthocyanins) was evaluated. Dietary bioactive compounds such as capsaicin, GABA, and tea offer an intervention framework for salt-sensitive hypertension by modulating central nervous system pathways and oxidative stress.
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