Key result
An overdose of of sertraline in a 40-year-old woman was associated with a marked prolongation of the QTc interval to 525 ms, which normalized after drug withdrawal.
Why the study?
Does sertraline overdose cause QT interval prolongation?
Case Report (n=1)
No
Does sertraline overdose cause QT interval prolongation?
Sertraline overdose may cause significant QT interval prolongation, highlighting the need for ECG monitoring in such cases.
Answers are grounded in this paper and cite their sources.
May support ECG monitoring in sertraline overdose; hypothesis-generating for QTc effects in SSRI toxicity.
BACKGROUND: Selective serotonin reuptake inhibitors (SSRIs) are the most common antidepressants used in first-world countries and are generally well tolerated. Specifically, less cardiovascular toxicity has been reported in comparison with tricyclic antidepressants. Here we report QT interval prolongation after an overdose of the SSRI sertraline. CASE PRESENTATION: A previously healthy female patient presented with an attempted suicide with overdoses sertraline (2250 mg), diazepam (200 mg), and temazepam (400 mg). Routine laboratory studies were normal and her ECG upon admission showed a normal QT interval. The next day, her ECG showed prolongation of the QTc interval up to 525 ms. After discontinuation of sertraline the QT interval normalized. Echocardiography and exercise electrocardiography were normal. After hospitalization, the patient resumed sertraline in the normally recommended dose and QT interval remained within normal ranges. CONCLUSION: It seems that the SSRI sertraline in overdose may cause QT interval prolongation.
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Boer et al. (2005) conducted a case report in Sertraline overdose (n=1). Sertraline was evaluated on QTc interval. An overdose of of sertraline in a 40-year-old woman was associated with a marked prolongation of the QTc interval to 525 ms, which normalized after drug withdrawal.
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