Why the study?
Does cardiac fibroblast-specific expression of IL-37 improve cardiac function and reduce fibrosis in diabetic cardiomyopathy mice?
Population
Diabetic cardiomyopathy mouse model and primary mouse cardiac fibroblasts cultured with high glucose and…
Comparison
Cardiac fibroblast-specific human IL-37b… vs Wild-type mice with diabetic cardiomyopathy…
Design
Preclinical
Key result
Cardiac fibroblast-specific expression of IL-37 ameliorated cardiac dysfunction and reduced collagen production in diabetic cardiomyopathy mice by promoting SOCS3-mediated JAK2-STAT3 inactivation.
Authors
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IL-37 may reduce fibrosis in diabetic cardiomyopathy models; leaves open human translation and requires prospective validation.
Does cardiac fibroblast-specific expression of IL-37 improve cardiac function and reduce fibrosis in diabetic cardiomyopathy mice?
IL-37 exerts antifibrotic effects and improves cardiac function in diabetic cardiomyopathy by promoting SOCS3-mediated JAK2-STAT3 inactivation.
Huang et al. (2024) studied Diabetic cardiomyopathy. Cardiac fibroblast-specific hIL-37b overexpression vs. Wild-type mice was evaluated on Cardiac dysfunction and fibrosis. Cardiac fibroblast-specific expression of IL-37 ameliorated cardiac dysfunction and reduced collagen production in diabetic cardiomyopathy mice by promoting SOCS3-mediated JAK2-STAT3 inactivation.