Why the study?
Gastrointestinal malignancies have high incidence and mortality rates with low overall survival, and lipid metabolism plays a crucial role in their progression, microenvironment regulation, and drug response.
Lipid metabolism plays a crucial role in the metabolic reprogramming, tumor microenvironment regulation, and drug response in gastrointestinal malignancies, highlighting its potential for biomarkers and targeted therapies.
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Supports lipid metabolism as a research priority in GI cancers; leaves open clinical translation pending prospective validation.
BACKGROUND: Gastrointestinal malignancies are a major public health concern worldwide, characterized by high incidence and mortality rates. Despite continuous advancements in existing treatment methods, overall survival rates remain low. Lipid metabolism plays a crucial role in the occurrence, progression, and treatment of gastrointestinal malignancies. Its involvement in the metabolic reprogramming of tumor cells, regulation of the tumor microenvironment, and drug response has become a research hotspot. MATERIALS & METHODS: This review summarizes current research related to lipid metabolism mechanisms, biomarkers, and therapies in GI cancers, with emphasis on its interaction with the tumor microenvironment.
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An et al. (2025) studied this question.
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