Disopyramide Therapy in Cats with Obstructive Hypertrophic Cardiomyopathy Non-Responsive to Carvedilol

Figures

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  Figure 1. Echocardiographic findings in a representative case showing a decrease in both the peak left ventricular outflow tract (LVOT) velocity and cardiac troponin I (cTnI) following disopyramide administration. Before treatment echocardiograms showed systolic anterior motion of the mitral valve and severe LVOT obstruction (A,B). Additionally, cTnI level was elevated. After treatment with carvedilol, LVOT obstruction persisted, and cTnI remained elevated (C,D). After the addition of disopyramide, LVOT obstruction improved, and cTnI returned to the normal range (E,F).

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  Figure 2. Line graphs of cardiac troponin I for Pre and Post disopyramide treatment in cats with obstructive hypertrophic cardiomyopathy. Blue dots show the individual data points. Pink bar shows the reference range of healthy cats (<0.121 ng/mL). cTnI: cardiac troponin I.

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  Figure 3. Line graphs of left ventricular outflow tract velocity (LVOTV) for Pre and Post disopyramide treatment in cats with obstructive hypertrophic cardiomyopathy: (a) LVOTVrest, (b) LVOTVexcited. Blue dots and red dots show individual data points of LVOTVrest and LVOTVexcited, respectively. Dot line shows the treatment goal of left ventricular outflow tract velocity (<3.5 m/s) in cats with obstructive hypertrophic cardiomyopathy in this study.