Key result
Higher hs-CRP correlates with cardiovascular, diabetic, and hepatic risk factors including AST and glucose.
Why the study?
Circulating C-reactive protein is a sensitive biomarker of systemic inflammation and may be associated with the development of diabetic, hepatic, and cardiovascular diseases.
Are circulating levels of hs-CRP associated with cardiovascular, diabetic, and hepatic biomarkers in healthy individuals?
Observational (n=438)
No
Are circulating levels of hs-CRP associated with cardiovascular, diabetic, and hepatic biomarkers in healthy individuals?
Effect estimate: r = 0.2139
p-value: p=<0.0001
High sensitivity C-reactive protein is positively correlated with several cardiovascular, diabetic, and hepatic biomarkers in individuals without preexisting clinical conditions.
hs-CRP correlates with risk markers in healthy adults; hypothesis-generating and requires prospective validation.
Biomarkers are early predictors of various disorders, circulating level of C-reactive protein is a sensitive biomarker of systemic inflammation and may also be associated with the development of diabetic, hepatic, and cardiovascular diseases. In the present study, we aimed to investigate the association between circulating levels of high sensitive C-reactive protein (hs-CRP) and various biomarkers for hepatic, diabetic, and cardiovascular health. The retrospective analysis included 438 individuals who were tested for these panels simultaneously at Vibrant America Clinical Laboratory. The study population included free-living individuals without any preexisting clinical conditions. Among the cardiovascular markers, a positive correlation and significant association was found between high levels of hs-CRP and serum levels of triglycerides (r = 0.0964, p −0.1423, p −0.1216, p < 0.0105) with circulating levels of hs-CRP. Among all the diabetic markers, glucose (r = 0.1547, p < 0.0011) and glycated serum protein (r = 0.1725, p < 0.0003) were positively correlated with circulating hs-CRP. In the hepatic panel, AST, a transaminase that plays a vital role in amino acid metabolism, was found to have a strong positive correlation with hs-CRP (r = 0.2139, p < 0.0001). In conclusion, the results clearly show the association of hs-CRP with diabetic, hepatic, and cardiovascular risk factors indicating its central value as a key marker for several lifestyle-associated disorders.
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Krishnamurthy et al. (2023) conducted an observational in Healthy individuals (free-living without preexisting clinical conditions) (n=438). High sensitivity C-reactive protein (hs-CRP) was evaluated on Correlation of hs-CRP with aspartate transaminase (AST) (r = 0.2139, p=<0.0001). High sensitivity C-reactive protein (hs-CRP) levels were significantly positively correlated with cardiovascular, diabetic, and hepatic risk factors, including AST (r = 0.2139) and glucose (r = 0.1547).
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