Key result
Elevated red blood cell distribution width identifies ruptured coronary plaques with ~72% sensitivity.
Why the study?
Higher RDW predicts MACE in CAD, but few studies have evaluated the relationship between RDW and vulnerable plaques.
Does elevated red blood cell distribution width predict coronary atherosclerotic plaque vulnerability detected by OCT in patients with cardiovascular diseases?
Observational (n=105)
Does elevated red blood cell distribution width predict coronary atherosclerotic plaque vulnerability detected by OCT in patients with cardiovascular diseases?
Elevated red blood cell distribution width (>13.85%) is associated with coronary plaque vulnerability and rupture as detected by OCT in patients with coronary artery disease.
BACKGROUND: A higher red blood cell distribution width (RDW) predicts major adverse cardiac events in patients with coronary artery disease (CAD). However, there are only a few studies regarding the relationship between RDW and vulnerable plaques. Thus, the purpose of the present study is to retrospectively explore the predictive value of the association between RDW and plaque vulnerability assessed by optical coherence tomography (OCT) in patients with cardiovascular (CV) diseases. METHODS: This study included 35 patients with stable angina pectoris (SAP) and 70 patients with the acute coronary syndrome (ACS). We documented clinical features as well as peripheral RDW. Plaque vulnerability was determined by OCT. We defined thin-cap fibroatheroma (TCFA) as a lipid-rich plaque (fibrous cap <65 μm thick). RESULTS: Plaque rupture was detected more frequently in patients with ACS compared with patients with SAP (62.9 vs. 2.9%, p<0.001, and the corresponding TCFA were 50.69±15.68 vs. 80.03±21.60 μm, p<0.001, respectively). A higher RDW was found in patients with ACS than in patients with SAP (p<0.001). A cut-off value of RDW >13.85% could detect ruptured plaque with a sensitivity of 72.3% and a specificity of 62%. CONCLUSION: TCFA and plaque rupture were detected more frequently in patients with ACS compared with SAP. Elevated RDW was positively the predictive value of the association between plaque vulnerability.
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Jin et al. (2022) conducted an observational in Stable angina pectoris and acute coronary syndrome (n=105). Red blood cell distribution width (RDW) vs. Stable angina pectoris was evaluated on Plaque rupture (p=<0.001). Elevated red blood cell distribution width (>13.85%) detected ruptured coronary plaques with 72.3% sensitivity and 62% specificity.
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