January 1, 2014Journal of Translational MedicineOpen Access

Significance of red cell distribution width measurement for the patients with isolated coronary artery ectasia

Q: What is the clinical evidence from this study?

Study design: Observational. Population: Isolated coronary artery ectasia (n=414). Intervention: Red cell distribution width vs. Normal controls and coronary artery disease patients. Primary outcome: Presence of isolated coronary artery ectasia (OR 1.38, 95% CI 1.11-2.97, p=0.003).

View Full Paper

Ask AI

Bookmark

Key result

Elevated baseline red cell distribution width was identified as an independent predictor for the presence of isolated coronary artery ectasia (OR 1.38).

Why the study?

Does red cell distribution width (RDW) predict the presence of isolated coronary artery ectasia in patients undergoing coronary angiography?

Study Design

Type

Observational (n=414)

Multicenter

Yes

Structured PICO

Does red cell distribution width (RDW) predict the presence of isolated coronary artery ectasia in patients undergoing coronary angiography?

Population

414 patients undergoing coronary angiography, including 113 with isolated coronary artery ectasia, 144 with coronary artery disease, and 157 normal controls, evaluated to determine the association between red cell distribution width and isolated CAE.

Exposure

Measurement of red cell distribution width (RDW)

Comparator

Patients with coronary artery disease (CAD) and angiographically normal controls

Outcome

Presence of isolated coronary artery ectasia (CAE)surrogate

Main Result

Odds Ratio: 1.38 (95% CI 1.11–2.97)

p-value: p=0.003

Elevated red cell distribution width (RDW) is an independent predictor for the presence of isolated coronary artery ectasia and correlates positively with hs-CRP, suggesting a potential inflammatory mechanism.

Limitations

Cross-sectional design cannot establish causality between increased RDW and isolated CAE
Relatively small sample size
Angiography cannot assess plaque burden in the wall of the coronary arteries
Relation of RDW level to the severity of isolated CAE or anatomical characteristics was not evaluated
Levels of folate, iron, and vitamin B12 were not evaluated
Prognostic role of RDW in patients with isolated CAE needs to be investigated
Cannot establish whether RDW has a causal role or is merely a marker of the disease process
Lack of intravascular imaging (e.g., ultrasound) to assess plaque burden in the coronary walls
Relation of RDW level to the severity or anatomical characteristics of isolated CAE was not evaluated
Prognostic role of RDW in patients with isolated CAE was not investigated

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Elevated RDW may flag isolated coronary ectasia on angiography; leaves open prospective validation and clinical utility.

Cite This Study

Li et al. (2014) conducted an observational in Isolated coronary artery ectasia (n=414). Red cell distribution width vs. Normal controls and coronary artery disease patients was evaluated on Presence of isolated coronary artery ectasia (OR 1.38, 95% CI 1.11-2.97, p=0.003). Elevated baseline red cell distribution width was identified as an independent predictor for the presence of isolated coronary artery ectasia (OR 1.38).

synapsesocial.com/papers/6a222eb789ae9bae15e23b5e https://doi.org/10.1186/1479-5876-12-62

Topics

Coronary artery disease Coronary CT angiography

View Full Paper

Ask AI

Bookmark

Significance of red cell distribution width measurement for the patients with isolated coronary artery ectasia

Study Design

Structured PICO

Main Result

Limitations

Discussion

Implication

Cite This Study

Topics

Significance of red cell distribution width measurement for the patients with isolated coronary artery ectasia

Study Design

Structured PICO

Main Result

Limitations

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider