Key result
Elevated red cell distribution width was independently associated with the presence of coronary artery disease (OR 2.593) in patients undergoing elective coronary angiography.
Why the study?
Coronary artery disease is the primary cause of death in developed countries and a leading cause of disease burden in developing countries.
Does red cell distribution width (RDW) correlate with the presence and severity of coronary artery disease in patients undergoing elective coronary angiography?
Cross-Sectional (n=124)
No
Does red cell distribution width (RDW) correlate with the presence and severity of coronary artery disease in patients undergoing elective coronary angiography?
Odds Ratio: 2.593 (95% CI 1.347–4.989)
p-value: p=0.004
Higher red cell distribution width is independently associated with the presence and severity of angiographic coronary artery disease, suggesting its potential utility as a simple predictive biomarker.
RDW may aid CAD prediction in elective angiography patients; hypothesis-generating and requires prospective validation before clinical adoption.
Background: Coronary artery disease (CAD) is the primary cause of death in developed countries and is one of the leading causes of disease burden in developing countries. Methods: This descriptive cross-sectional study included 124 purposively selected patients who underwent elective CAG in the department of cardiology, Chittagong medical college hospital, Chattogram, from July 2020 to June 2021. SPSS 23.0 software was used for processing and analysis at the end of the data collection period. Results: According to the Gensini score, patients were categorized into two groups (score <30 and ≥30). There were no significant differences between the two groups concerning BMI, smoking, hypertension, DM, F/H of CAD, statin or beta-blocker use, or the levels of hemoglobin, hematocrit, MCV, MCH MCHC, and creatinine. However, the mean age was older, and there were more males in the severe CAD group. The percentage of dyslipidemia was significantly higher in patients with Gensini score ≥30 than in patients with <30. RDW (OR: 2.629; 95% CI: 1.425-4.484; p=0.002) and age (OR: 1.058; 95%CI: 1.00-1.111; p=0.027) were independently correlated with the severity of CAD. The AUROC for red cell distribution width (RDW) was 0.915 with a p<0.001 for predicting CAD on CAG. It indicated a statistically significant association of RDW with the presence of CAD. A cut-off value of 13.65% RDW had a sensitivity of 80% and specificity of 84.2% for the prediction of CAD. There were no significant differences between patients with and without angiographic CAD for BMI, hypertension, DM, statin, or beta-blocker use, or of the levels of hemoglobin, hematocrit, MCV, MCH, MCHC, and creatinine. However, the mean age was older, and there were more males in the CAD group. The percentage with dyslipidemia, smoking, and F/H of CAD was significantly higher in patients with CAD than in patients without CAD. The data indicate that only RDW was independently correlated with the presence of CAD (OR: 2.593; 95% CI: 1.347-4.989; p=0.004). Conclusions: RDW is associated with the presence of CAD and suggests that it might be a readily available test for predicting coronary artery diseases.
No takes yet. Share an insight, caveat, or question.
Latif et al. (2023) conducted a cross-sectional in Coronary artery disease (n=124). Red cell distribution width (RDW) was evaluated on Presence of angiographic coronary artery disease (OR 2.593, 95% CI 1.347-4.989, p=0.004). Elevated red cell distribution width was independently associated with the presence of coronary artery disease (OR 2.593) in patients undergoing elective coronary angiography.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: