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March 5, 2009HeartOpen Access

Plasma CAV1 and -2 levels in patients with CRPC were significantly higher than in those with non-CRPC (CAV1, p=0.003; CAV2, p<0.001) and were significantly correlated with each other (p<0.001).

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Population

58 Japanese men with prostate cancer, along with PC3 and LNCaP cell lines.

Design

Other

Authors

KSKoichi SakabeNFNobuo FukudaYFY Fukuda

Discussion

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Overview

Elevated CAV1/2 levels associate with CRPC; hypothesis-generating for biomarker or target roles, should not yet change practice.

Structured PICO

P
Population
58 Japanese men with prostate cancer (36 with castration-resistant prostate cancer [CRPC] and 22 with hormone-sensitive prostate cancer [non-CRPC]), along with PC3 (CRPC) and LNCaP (non-CRPC) cell lines.
O
Outcome
Plasma levels of CAV1 and CAV2 and their association with prostate cancer progressionsurrogate

Plasma CAV1 and CAV2 levels are significantly elevated in castration-resistant prostate cancer, suggesting their potential as therapeutic targets.

Cite This Study

Sakabe et al. (2009) studied this question.

synapsesocial.com/papers/6a0e9bcaf59e0974004c47ebhttps://doi.org/10.1136/hrt.2008.152561
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