Key result
RAS exhibits complex immunomodulatory properties across oncology, intensive care, and solid organ transplantation.
Why the study?
Beyond blood pressure homeostasis, the renin-angiotensin system exerts effects on proliferation, fibrosis, and inflammation, prompting an evaluation of its immunomodulatory properties across distinct clinical fields.
Design
State-of-the-art review
Authors
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Should not yet change RAS inhibitor use; hypothesis-generating for targeted immunomodulation in oncology and transplantation.
This review highlights the complex direct and indirect interactions of the renin-angiotensin system with immunomodulatory pathways beyond blood pressure homeostasis.
Laghlam et al. (2021) conducted a review in Immunomodulation in oncology, intensive care, and solid organ transplantation. Renin-angiotensin system modulators was evaluated. The renin-angiotensin system exhibits complex immunomodulatory properties across oncology, intensive care, and solid organ transplantation, warranting further research into targeted RAS treatments.
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