Key result
Cardiac resynchronization-defibrillator therapy resulted in an immediate 30% increase in stroke volume and 35% decrease in mitral regurgitation in a patient with a narrow QRS complex.
Why the study?
Does cardiac resynchronization therapy improve hemodynamics in a heart failure patient with a narrow QRS complex and mechanical dyssynchrony?
Case Report (n=1)
Does cardiac resynchronization therapy improve hemodynamics in a heart failure patient with a narrow QRS complex and mechanical dyssynchrony?
Cardiac resynchronization therapy may provide immediate hemodynamic benefits in heart failure patients with narrow QRS duration who have mechanical dyssynchrony identified by tissue synchronization imaging.
Answers are grounded in this paper and cite their sources.
Should not change narrow-QRS CRT practice; hypothesis-generating for mechanical dyssynchrony guidance.
This report described an 81-year-old woman with severe symptomatic heart failure, reduced ejection fraction, mitral regurgitation, and an electrocardiographic QRS width of 118 ms who had ventricular dyssynchrony identified by echocardiographic tissue synchronization imaging. Because of her severe heart failure symptoms on maximal medical therapy, referral to implant a defibrillator, and mechanical dyssynchrony, she underwent cardiac resynchronization-defibrillator therapy with lateral left ventricular lead placement. This resulted in an immediate 30% increase in stroke volume and 35% decrease in mitral regurgitation. Echocardiographic tissue synchronization imaging may play a role in identifying mechanical dyssynchrony in patients with narrow QRS duration who may potentially benefit from cardiac resynchronization therapy.
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Dohi et al. (2005) conducted a case report in Severe symptomatic heart failure with reduced ejection fraction and ventricular dyssynchrony (n=1). Cardiac resynchronization-defibrillator therapy was evaluated on Stroke volume and mitral regurgitation. Cardiac resynchronization-defibrillator therapy resulted in an immediate 30% increase in stroke volume and 35% decrease in mitral regurgitation in a patient with a narrow QRS complex.
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