Key result
Three DMD patients develop rare concurrent HCM in a longitudinal case series.
Why the study?
Only two separately reported cases had previously described the combined pathology of Duchenne muscular dystrophy and hypertrophic cardiomyopathy.
Case Report (n=3)
This case series expands upon previous reports by describing longitudinal findings in three patients with Duchenne muscular dystrophy who developed hypertrophic cardiomyopathy.
Answers are grounded in this paper and cite their sources.
Warrants vigilance for hypertrophic cardiomyopathy in Duchenne muscular dystrophy; case report leaves open prevalence and management questions.
Duchenne muscular dystrophy is characterised by fibrofatty replacement of muscle, resulting in dilated cardiomyopathy. Hypertrophic cardiomyopathy affects 1:200-1:500 people and is characterised by asymmetric ventricular septal hypertrophy. To date, there have been two separately reported cases describing the combined pathology of these disorders. Herein, we expand upon these reports with a case series describing longitudinal findings in three patients with Duchenne muscular dystrophy who developed hypertrophic cardiomyopathy.
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Greiner et al. (2024) conducted a case report in Duchenne muscular dystrophy and hypertrophic cardiomyopathy (n=3). Three patients with Duchenne muscular dystrophy developed hypertrophic cardiomyopathy, demonstrating the rare combined pathology of these two disorders in a longitudinal case series.
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